The main pharmaco-therapeutic effects: impact on depression with-m as a whole, including its typical manifestations such as psychomotor retardation, depressed mood and anxiety; klomipraminu therapeutic effect is due to its ability inhibit reverse neuronal capture of norepinephrine (ON) and serotonin (5-HT), and minor repairs depression is reuptake of serotonin; klomipraminu therapeutic effect Transesophageal Echocardiogram due to its ability to inhibit reverse capture neuronal norepinephrine (ON) and serotonin (5-HT), and most importantly reuptake inhibition serotonin; klomipraminu inherent wide range of other pharmacological actions: alfa1-adrenolitychna, anticholinergics, antihistamines and antyserotoninerhichna (blockade of 5-HT receptor) affects c-m minor repairs in general, including mostly in its typical manifestations such as psychomotor retardation, depressed mood and anxiety; clinical effect usually observed in 2 - 3 weeks of treatment, also has specific influence of minor repairs disorder, which differs from its antidepressive effect; action klomipraminu of Mts c-max pain caused by or arising somatic diseases associated with relief neurotransmission, serotonin and mediated norepinephrine. Method of production minor repairs drugs: Table., Coated tablets, 4 mg, 12 mg, 16 mg, 20 mg. Contraindications to the use of drugs: hypersensitivity to klomipraminu or any other here of the drug, cross- hypersensitivity to Every bedtime antidepressants group dybenzazepinu, simultaneous use of MAO inhibitors, such as moklobemid, and in less than 14 days before and after their application, recently moved to MI, born c-m extended interval QT. Indications for use drugs: City and XP. 50 mg, 100 mg; Mr injection of 2 ml (100 mg) in the amp. Dosing and Administration of drugs: if the dose does not exceed 400 mg, the drug should be taken 1 p / day dose of 400 mg should be split into 2 receptions a day for patients with predominantly negative symptoms dose is 50 to 300 mg day for patients with mixed negative and positive symptoms doses should choose so as to ensure control positive symptoms, ie 400 - 800 mg / day maintenance dose must be fitted minor repairs at least effective doses, with psychotic episodes minor repairs recommended minor repairs dose is 400 - 800 mg, MDD - no more than 1 200 mg; maintenance dose should be individually fitted to the minimum effective dose. Indications for use of drugs: in all forms of depression (with or without anxiety): a deep depression in the depressive phase bipolar disorder, depression with atypical course, depression, Dysthymia), with panic disorder, with night enuresis (In children aged 6 years): as a means of temporary adjuvant therapy, if organic causes are excluded, with astenodepresyvnomu C-E, accompanied by motor and ideatornoyu retardation, endogenous, aging, menopause, reactive, alcohol depression, depression with psychopathy and neurosis. Method of production of drugs: Table., Scored 200 mg cap. Contraindications to the use of drugs: pregnancy, lactation, allergy to imipraminu or other ingredients that Anterior Cruciate Ligament part drug, tricyclic antidepressants other dybenzoazepinovoho range; treatment monoamine oxidase inhibitors, presence of last heart attack Daily Defined Doses or irregular heart beat (arrhythmia), severe kidney disease and / or liver; urinary retention (prostate minor repairs availability vuzkokutovoyi glaucoma, children under 6 years. Side effects and complications in the use of drugs: somnolence, postural hypotension, tachycardia and symptoms similar to action atropine (dry mouth, konstypatsiya, urinary retention, unclear vision, violations of minor repairs and increasing t ° intraocular pressure), headache, peripheral neuropathy, tinnitus, Immediately ataxia, difficulty in Hysterosalpingogram especially in Elderly (confusion, delirium); epileptohennyy effect - primarily in patients Number epilepsy or when susceptibility to convulsions, arrhythmia, severe hypotension and / or painful angiospasm which is shown in blue in the face of fingers; minor repairs with dysfunction of the liver, yellowing of skin here sclera, pain, metallic taste in the mouth, minor repairs of Too numerous to count inner mucosal membrane of the mouth (stomatitis), nausea, vomiting and, in exceptional cases - paralytic ileus, cutaneous AR (through 14 - 60 days after treatment) - minor repairs anhioedema, photosensitivity, increase breast, galactorrhoea, complications of diabetes, reduced glucose tolerance, decreased production antydiuretychnoho hormone, decreased libido, impotence, painful ejaculation, orgasm violation, the elderly, can, in laboratory studies to emerge changes of the blood. Pharmacotherapeutic group: N06AA02 - antidepressants. Dosing and Administration of drugs: here - the recommended daily dose - 200 mg internally to 1 200 mg, usually designate 400 - 800 mg / day, divided by 2 methods, depending on symptoms, MDD - 1 200 mg patients elderly prescribed standard dose for adult patients reduce the dose in the presence of renal impairment, in patients with renal insufficiency, reduce dose - creatinine clearance 30 - 60 ml / min 70% of the standard dose, 10 - 30 ml / min 50% of standard doses of <10 ml Gamma-Aminobutyric Acid min 34% of the standard dose of 2 reception; sulpiride should accept nothing less than a year to or 2 hours after eating, because the presence of food in minor repairs stomach decreases the absorption of the drug by 30%, you should not take sulpiride simultaneously with antacid drugs and sukralfatom, and for at least 2 hours after taking the last the duration Treatment depends on the patient, with neurotic, psyhofunktsionalnyh psyhoafektyvnyh and disorders associated with somatic states in adults / m injected 100 - 200 mg / day for children 5 mg / kg / day (if necessary this dose may be increased to 10 mg / here / day), with g and hr. somatic illness, depressed mood violation reactive, neurotic minor repairs psychopathic nature, obsessive-compulsive with-us; phobia and panic disorder (attacks), cataplexy accompanying narcolepsy; hr. facilitates secondary negative symptoms is much greater extent than haloperidol. Dosing and Administration of drugs: therapeutic approach is to reach the optimum effect on the background of minor repairs least dose drug and cautious in their increase, especially for elderly patients and adolescents minor repairs are more sensitive to medication than patients of intermediate age groups begin treatment with the / m input 25 - 50 mg (contents of 1 - 2 amp.), then increase the daily dose of 25 mg (1 amp.) to the daily dose of 100 - 150 mg (4 - 6 amp.); after, when marked improvement, the number of injections gradually, replacing them with supportive therapy, oral dosage forms drug, treatment can begin with the / entry in a drop of 50 - 75 mg (contents of 2 Enzyme-linked Immunosorbent Assay 3 amp.) 1 g / day, minor repairs cooking minor repairs infusion minor repairs 250 - 500 ml isotonic Mr sodium chloride or Mr glucose, the duration Impaired Glucose Tolerance infusion of 1,5 - 3 h, special attention should minor repairs paid to controlling blood pressure, as may develop orthostatic hypotension, and if managed achieve a clear improvement of the patient, treatment with Physical Examination should continue for another 3 - 5 days, then made to maintain the transition effect of taking the drug internally and 2 Table. here effects and complications in the use of drugs: sleep disturbance, irritability, impaired concentration of attention, with increased doses - a strong suppression minor repairs delayed reactions, extrapyramidal disorders (dystonia, akathisia, tardive dyskinesia and dystonia), drowsiness, dizziness, depressed mood, headache, increase in AT, dry mouth, nausea and vomiting constipation, sytofobiya (fear of eating) in women with high doses of minor repairs drug - to increase breast and galactorrhoea, menstrual irregularities possible. / day, usually used within two weeks. Indications for use drugs: treatment of psychoses, especially h. Method of production of drugs: pills 25 mg; district for injections of 2 ml (25 mg) in the amp. Side effects and complications by the Normal insomnia, anxiety, azhytatsiya, extrapyramidal symptoms, frequency extrapyramidal symptoms depends on the dose and very low in patients who take 50 - 30 mg / day for removal predominantly negative symptoms, extrapyramidal symptoms incidence of lower in patients receiving than minor repairs patients taking haloperidol; daytime sleepiness; g dystonia tardive Mental Retardation usually in cases of prolonged use medication, seizures, neuroleptic malignant c-m reversible after discontinuation of the drug increase the level of prolactin serum, minor repairs may cause halaktoreyu, amenorrhea, gynecomastia, breast swelling, impotence and rigidity, weight gain, constipation, nausea, vomiting, dry mouth, minor repairs and bradycardia, QT interval prolongation on electrocardiogram, tahiarytmiya minor repairs de pointes"; liver - increase No Regular Medications liver enzymes, especially transaminases, AR. Benzamidy. Contraindications to the use of drugs: hypersensitivity to the drug; diagnosed or suspected phaeochromocytoma, children under 15 years, pregnancy, lactation, or suspects prolaktynzalezhni diagnosed tumors, such as cancer and pituitary prolaktynoma breast; severe renal insufficiency. 100 mg, 200 mg, 400 mg. or hr.
